**Notice of Funding Opportunity (NOFO)****Funding Opportunity Title:** Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (R01 Clinical Trial Optional)**Funding Opportunity Number (FON):** RFA-CA-25-005**Catalog of Federal Domestic Assistance (CFDA) Number:** 93.394**1. Overview Information****Participating Organization(s):*** National Institutes of Health (NIH)* National Cancer Institute (NCI)**Estimated Total Funding:** $700,000**Estimated Number of Awards:** 3**Anticipated Award Dates:*** Start date: April 04, 2025* End date: December 2025 or October 2025 (clinical trial proposals)**2. Full Text of Announcement****I. Notice of Funding Opportunity Description****Purpose**This NOFO encourages revision applications from currently funded NCI hypothesis-driven R01 research projects. The applicants should propose to expand upon the original research question(s) or otherwise accelerate progress for the parent study by incorporating a new technical approach or device developed through support from the NCI Innovative Molecular Analysis Technologies (IMAT) program.Awards from this NOFO are meant to incentivize independent validation and to accelerate the adoption of these emerging technologies by appropriate research communities.**Goal(s)**The goal of this NOFO is to:* Identify cancer risks and risk reduction strategies, identify factors that cause cancer in humans, and discover and develop mechanisms for cancer prevention and preventive interventions in humans.* Improve screening and early detection strategies and develop accurate diagnostic techniques and methods for predicting the course of disease in cancer patients.* Develop the means to cure as many cancer patients as possible and to control the disease in those patients who are not cured.* Provide fundamental information on the cause and nature of cancer in people.* Reduce cancer risk, incidence, morbidity, and mortality and enhance quality of life in cancer survivors.**Non-Responsive Projects**Applications seeking to incorporate technology platforms that are commercially available to the research community;Applications proposing to incorporate technologies that were not developed through the support of the NCI IMAT program;Applications proposing to use technologies that were developed by a PI on the parent R01;Applications seeking support during a period of no-cost extension.**3. Eligibility Information****Eligible Applicants*** Nonprofits with 501(c)(3) IRS status (Other than Institutions of Higher Education)* Nonprofits without 501(c)(3) IRS status (Other than Institutions of Higher Education)* For-Profit Organizations (Other than Small Businesses)* Small Businesses* Higher Education Institutions* State Governments* County Governments* City or Township Governments* Native American Tribal Governments (Federally Recognized)* Native American Tribal Governments (Other than Federally Recognized)* Indian/Native American Tribal Organizations (other than Federally recognized tribal governments)* Faith-based or Community-based Organizations* Public Housing Authorities/Indian Housing Authorities* Independent School Districts* Public Health Service/Indian Health Service Tribal/Urban Indian Health Programs* Foreign Institutions**4. Application and Submission Information*** **Instructions for Application Submission:** Follow the instructions in the Research (R) Instructions in the How to Apply - Application Guide, except where instructed to do otherwise (in the NOFO or in the Notice from NIH Guide for Grants and Contracts).* **Letter of Intent (LOI):** Although not required, submitting an LOI including the information listed in Part 1. Overview Information is recommended.* **Required Application Package:** Resubmission and Revision applications from active NCI R01 awardees.* **Research Strategy:** The research strategy is limited to 6 pages for this NOFO.* **Number of Applications:** Applicant organizations may submit more than one application, provided that each application is scientifically distinct.* **SF424(R&R) Project/Performance Site Locations:** Follow all instructions in the How to Apply - Application Guide.* **SF424(R&R) Other Project Information:** Follow all instructions in the How to Apply - Application Guide.* **SF424(R&R) Senior/Key Person Profile:** Follow all instructions in the How to Apply - Application Guide.* **R&R or Modular Budget:** Follow all instructions in the How to Apply - Application Guide.* **R&R Subaward Budget:** Follow all instructions in the How to Apply - Application Guide.* **PHS 398 Cover Page Supplement:** Follow all instructions in the How to Apply - Application Guide.* **PHS 398 Research Plan:** * Technology to be incorporated: Identify the IMAT-supported technology being incorporated. * Specific Aims: List the specific objectives of the proposed research in the context of the specific aims of the parent award. * Research Strategy: * Importance of Research: Describe the relevant tools and approaches currently used to pursue the parent study. * Rigor and Feasibility: Describe the proposed project and how it addresses the specific aspects listed below: * Key advantages that the IMAT-supported technology offers that may overcome hurdles described for the parent study. * Beyond the value of the proposed study for advancing cancer research, briefly describe how the proposed project may serve to independently validate the usefulness of the new technology for the cancer research community.* **Resource Sharing Plan:** Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the How to Apply - Application Guide.* **Other Plan(s):** * Data Management and Sharing Plan: All instructions in the How to Apply - Application Guide must be followed. * Appendix: Only limited Appendix materials are allowed.**5. Application Review Information****Review Criteria:*** Importance of the Research (Significance and Innovation)* Rigor and Feasibility (Approach)* Expertise and Resources (Investigator(s) and Environment)**Additional Review Considerations:*** Authentication of Key Biological and/or Chemical Resources* Budget and Period of Support**6. Award Administration Information*** **Award Notices:** NoA is the official authorizing document notifying the applicant that an award has been made and that funds may be requested from the designated HHS payment system or office.* **Federal and HHS Specific Policy Requirements:** * Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards (2 CFR Part 200) * NIH Grants Policy Statement * Nondiscrimination laws * Cybersecurity Act of 2015, Division N, § 405, Pub. Law 114-113, 6 USC § 1533(d)**7. Agency Contacts****Application Submission Contacts:*** eRA Service Desk: https://www.era.nih.gov/need-help (preferred method of contact)* General Grants Information: [email protected] (preferred method of contact)* Grants.gov Customer Support: Contact Center Telephone: 800-518-4726**Scientific/Research Contact:*** Kelly Crotty, Ph.D. National Cancer Institute (NCI)* Telephone: 240-255-0917* Email: [email protected]**Referral Officer:*** National Cancer Institute (NCI)* Telephone: 240-276-6390* Email: [email protected]**Financial/Grants Management Contact:*** Sean Hine National Cancer Institute (NCI)* Telephone: 240-276-6291* Email: [email protected]**8. Other Information*** **Authority and Regulations:** Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.