## Overview**The National Institute on Drug Abuse (NIDA) at the National Institutes of Health (NIH)** requests applications for Cutting-Edge Basic Research Awards (CEBRA). These are highly innovative, high-risk, high reward projects that will build on existing work and lead to new research directions and applications in relation to the etiologies, pathophysiology, prevention, or treatments of substance use disorders (SUDs). The proposed research should break new ground or extend previous discoveries toward new directions or applications. Beyond hypothesis-driven research, this announcement also encourages the development of new tools and technologies, or the identification of new model systems that have the potential to greatly impact SUD research.## Eligible Applicants* Public and private institutions of higher education* Nonprofit organizations* Governmental, Indian/Native American tribes or tribal organizations, faith-based or community-based organizations* For-profit organizations## Timeline| Event | Date ||---|---|| Letter of Intent due | 30 days prior to the application due date || Application due | December 30, 2024 || Earliest start date | July 2025 |## Award Information* **Award range:** $275,000 per year* **Project period:** 2 years (total project period: 2-5 years)* **Estimated Number of Awards:** 10-15## Application Review InformationApplications will be evaluated based on:**1. Importance of the Research*** Significance and Innovation: Reviewers will evaluate the importance of the proposed research, considering its potential impact on the field of addiction research.**2. Rigor and Feasibility*** Approach: Reviewers will assess the scientific quality of the proposed work and its feasibility, including the team's preparedness to address any potential challenges.**3. Expertise and Resources*** Investigators: Reviewers will evaluate the qualifications of the research team and the adequacy of the institutional resources to support the proposed research.## Application InstructionsApplications must be submitted electronically through the NIH's electronic Research Administration (eRA) Commons system. For assistance with electronic submissions, consult the eRA Commons Help Center.## Contact InformationFor scientific inquiries, contact Dr. Tristan D. McClure-Begley ([email protected]) or Dr. Dharmendar Rathore ([email protected]). For financial/grants management questions, contact Jen Schermerhorn ([email protected]).